Product Name: Monomethyl Glutarate
Chemical Name: 5-Methoxy-5-oxopentanoic acid
Synonyms: 1-Methyl glutaric acid, Monomethyl pentanedioic acid
Recommended Use: Intermediate in pharmaceuticals, cosmetics, specialty chemicals
Manufacturer: [Company Address, Emergency Contact, Phone]
CAS Number: 626-51-9
Molecular Formula: C6H10O4
Molecular Weight: 146.14 g/mol
Relevant Identified Uses: Research and industrial applications
GHS Classification: Not classified as hazardous under GHS, but dusty conditions can irritate eyes, skin, or respiratory system
Signal Word: None
Hazard Statements: May cause irritation to eyes, skin, and respiratory tract if handled improperly or exposed for prolonged periods
Pictograms: None required
Precautionary Statements: Avoid inhaling dust or vapors, wear protective gloves and eye protection, wash hands thoroughly after handling, use in well-ventilated areas
Other Hazards: Combustible dust under certain conditions, avoid accumulation of dust when handling large quantities
Chemical Identity: Monomethyl Glutarate
Purity: ≥ 98%
Impurities: Trace amounts of dimethyl glutarate or glutaric acid as byproducts, less than 2%
Ingredients contributing to hazard: No classified hazardous ingredients above threshold levels
Inhalation: Move affected person to fresh air. Seek medical attention if breathing becomes difficult or symptoms persist.
Skin Contact: Remove contaminated clothing, wash skin with soap and plenty of water. Seek medical attention if irritation develops.
Eye Contact: Rinse immediately with plenty of running water for at least 15 minutes. If redness or irritation continues, consult an ophthalmologist.
Ingestion: Rinse mouth with water. Do not induce vomiting. Seek medical advice if discomfort or symptoms develop.
General Notes: Provide the product label or safety data when seeking medical care. Ensure responders are protected with appropriate PPE.
Suitable Extinguishing Media: Use water spray, foam, dry chemical, or carbon dioxide for small fires involving organic solids.
Unsuitable Extinguishing Media: Do not use high-pressure water streams which may spread powder.
Specific Hazards: Dust can form explosive mixtures with air in uncontained handling or storage.
Special Protective Equipment: Firefighters must use self-contained breathing apparatus (SCBA) and full protective gear.
Hazardous Combustion Products: Burning product gives off irritating fumes including carbon monoxide, carbon dioxide, and organic acids.
Advice for Firefighters: Prevent contaminated run-off from entering surface water, sewers, or the environment.
Personal Precautions: Wear chemical-resistant gloves, goggles, and dust mask during cleanup. Remove ignition sources. Ensure adequate ventilation.
Environmental Precautions: Prevent product entry into drains, sewers, or surface water using dikes or absorbent barriers.
Methods for Cleaning Up: Collect dry material with a vacuum equipped with HEPA filter or by sweeping up gently. Place in labeled waste container for disposal.
Spill Response: For large spills, evacuate area and consult emergency response team. Avoid raising dust in enclosed spaces.
Handling: Minimize dust formation. Use local exhaust ventilation in processing areas. Do not smoke, eat, or drink while handling. Keep away from heat sources.
Storage Conditions: Store in tightly closed, labeled containers. Place in dry, cool, and well-ventilated location, away from incompatible materials such as strong oxidizers.
Storage Stability: Keep product away from moisture, direct sunlight, and temperature extremes. Properly label all containers.
Other Recommendations: Ground and bond containers and equipment to prevent electrostatic discharge where possible.
Occupational Exposure Limits: No established regulatory limits for Monomethyl Glutarate in most jurisdictions.
Engineering Controls: Use local exhaust ventilation and process enclosures where dust or vapors may form. Monitor workplace concentrations.
Personal Protective Equipment: Wear safety goggles or face shield, nitrile or neoprene gloves, long-sleeved clothing and protective shoes. Use NIOSH-approved dust respirators in case of significant exposure.
Hygiene Measures: Wash hands and face after handling. Remove and clean contaminated clothing before reuse.
Appearance: White to off-white crystalline powder
Odor: Mild, slightly acidic
Odor Threshold: Not available
pH (1% solution): Approx. 3.2 - 4.0
Melting Point: 75°C – 80°C (depends on purity)
Boiling Point: Not determined (decomposes on heating)
Flash Point: Approx. 170°C (closed cup, combustible in dust form)
Flammability: Not readily flammable solid but dust may ignite under appropriate conditions
Vapor Pressure: Negligible at room temperature
Vapor Density: Not applicable
Solubility: Freely soluble in water, sparingly soluble in ethanol
Partition Coefficient (log Kow): Not determined
Decomposition Temperature: Above 170°C, with release of CO, CO2, organic vapors
Density: Approx. 1.3 g/cm3
Chemical Stability: Stable under normal storage and handling conditions. Hygroscopic under humid environments.
Reactivity: Does not react violently with most chemical classes under typical use.
Possibility of Hazardous Reactions: Can react with strong oxidizers, generating heat and gases.
Conditions to Avoid: Excessive heat, sparks, open flame, moisture, strong acids and bases
Incompatible Materials: Strong oxidizing agents, reducing agents, acids
Hazardous Decomposition Products: Burning or decomposition yields carbon oxides and low molecular weight carboxylic acids.
Acute Toxicity: Low oral, dermal, and inhalation toxicity in animal studies; LD50 (oral, rat) estimated over 2000 mg/kg
Skin Irritation: May cause mild to moderate irritation on prolonged or repeated contact
Eye Irritation: Causes irritation, redness, watering, or discomfort
Respiratory Sensitization: Inhalation of dust can cause throat irritation, coughing, sneezing
Carcinogenicity: No evidence of carcinogenic potential based on available data
Mutagenicity: No evidence for genotoxicity from short-term laboratory tests
Chronic Effects: No chronic effects reported at occupational exposure levels
Other Health Effects: Sensitive individuals may experience exacerbation of allergic or respiratory conditions
Ecotoxicity: Biodegradable compound with low bioaccumulation potential; not persistent in aquatic or terrestrial environments
Aquatic Toxicity: Estimated EC50 (daphnia, 48hr) > 100 mg/L, low risk to aquatic life
Persistence and Degradability: Rapidly biodegraded under aerobic conditions by soil and water microorganisms
Bioaccumulation Potential: Does not bioaccumulate significantly due to high water solubility
Mobility in Soil: Compound remains mobile in aqueous environments, but breaks down into harmless metabolites
Special Precautions: Prevent excessive release into natural waterways or sewer systems.
Waste Disposal Methods: Collect and place material in sealed containers for disposal as chemical waste. Follow local, state, and federal regulations.
Contaminated Packaging: Dispose of empty packaging as hazardous waste or recycle if permitted. Rinse thoroughly before disposal.
Other Recommendations: Do not flush large quantities into sewer. Avoid disposal to surface waters. Consult licensed waste contractor for appropriate disposal method.
UN Number: Not regulated as dangerous goods
UN Proper Shipping Name: Not classified as hazardous under IMDG, IATA, or USDOT regulations
Transport Hazard Class: Not applicable
Packing Group: Not applicable
Special Precautions: Transport in tightly closed, labeled containers. Protect from moisture, heat, and physical damage. Prevent accidental release by keeping containers upright during handling and transport.
Regulatory Status: Not listed as a hazardous chemical under OSHA Hazard Communication Standard, TSCA, REACH, or other major chemical control laws
Inventory Listings: Present on TSCA, EINECS/ELINCS, DSL, AICS, and various global chemical inventories
Labelling Requirements: No special hazard labeling required, but containers must indicate chemical identity and key handling information.
Workplace Regulations: General duty to inform workers of safe handling. Use engineering and administrative controls to limit dust exposure where necessary.
