Product Name: 4’-Hydroxyacetophenone
Synonyms: p-Hydroxyacetophenone, Parahydroxyacetophenone
Chemical Formula: C8H8O2
CAS Number: 99-93-4
Recommended Use: Intermediate for pharmaceuticals, flavor, and fragrance manufacturing
Supplier: Refer to product label information for current distributor
Emergency Telephone Numbers: Poison Control Center, national emergency services
GHS Classification: Eye Irritant (Category 2A), Skin Irritant (Category 3), Acute Toxicity (Oral, Category 5)
Signal Word: Warning
Hazard Statements: Causes eye irritation, may cause mild skin irritation, harmful if swallowed in high amounts
Precautionary Statements: Use gloves and goggles, wash thoroughly after handling, avoid inhalation of dust or vapors, do not eat, drink, or smoke while handling
Label Elements: Exclamation mark pictogram, hazard code H319, H316, H303
Chemical: 4’-Hydroxyacetophenone
CAS Number: 99-93-4
EC Number: 202-802-8
Purity: ≥98%
Impurities: Residual solvents and related phenolic compounds at trace levels
Inhalation: Remove to fresh air, monitor breathing, seek medical attention for persistent symptoms
Eye Contact: Rinse cautiously with water for several minutes, remove contact lenses if present, continue rinsing, consult medical care if irritation persists
Skin Contact: Remove contaminated clothing, wash skin with soap and plenty of water, seek attention if redness or discomfort remains
Ingestion: Rinse mouth, do not induce vomiting, drink water if conscious, obtain medical advice immediately
Suitable Extinguishing Media: Use water spray, dry chemical, CO2, or foam as appropriate for surrounding materials
Specific Hazards: May release carbon oxides and irritating fumes if involved in fire
Protective Equipment: Firefighters need self-contained breathing apparatus and full protective gear
Explosion Data: Fine dust may form explosive mixtures with air under high-energy conditions
Special Procedures: Contain run-off, avoid inhaling combustion products
Personal Precautions: Evacuate unnecessary personnel, ventilate area, avoid breathing dust, wear protective equipment
Environmental Precautions: Prevent spillage from entering drains or waterways
Containment Methods: Sweep up material without creating dust, place collected reagents in sealed containers
Cleanup Procedures: Wash contaminated surfaces with water and detergent, dispose according to local guidelines
Handling: Use in a well-ventilated area, avoid contact with eyes and skin, minimize generation of dust, wash hands after use
Storage: Keep container tightly closed, store in cool, dry, well-ventilated place away from incompatible substances such as strong oxidizers
Incompatible Products: Strong acids, alkalis, and oxidizing agents
Other Precautions: Use only non-sparking tools, prevent static accumulation
Occupational Exposure Limits: No specific TLV or OSHA PEL assigned, keep airborne concentrations as low as possible
Engineering Controls: Local exhaust ventilation preferred, safety showers and eye-wash stations recommended in work area
Personal Protective Equipment: Safety goggles, nitrile or neoprene gloves, lab coat or apron, NIOSH-approved respirator if dust forms
Hygiene Measures: Do not eat or drink during handling, launder contaminated clothing before reuse, practice good industrial hygiene
Appearance: White to pale yellow crystalline solid
Odor: Mild, sweet; slight phenolic scent
Molecular Weight: 136.15 g/mol
Melting Point: 109–111°C
Boiling Point: 285°C (estimated, decomposes)
Solubility: Soluble in ethanol, ether, and partially soluble in water
pH: Not applicable for solid
Vapor Pressure: Negligible at ambient temperature
Partition Coefficient: Log Kow ~1.2
Flash Point: >150°C (closed cup, approximate)
Chemical Stability: Stable under recommended storage and handling conditions
Reactivity: Inert to most laboratory conditions, reacts slowly with strong oxidizers
Hazardous Decomposition Products: Carbon monoxide, carbon dioxide, phenolic fumes
Polymerization: Not known to occur
Conditions to Avoid: High temperatures, open flame, static electricity build-up, prolonged exposure to light or humidity
Acute Toxicity: LD50 (oral-rat): ~1,990 mg/kg
Potential Health Effects: Causes eye irritation, may induce mild irritation to mucous membranes, rare allergic response in sensitive individuals
Chronic Effects: Long-term exposures or ingestion may present mild hepatotoxicity, no evidence of carcinogenicity or mutagenicity found in available data
Sensitization: Not classified as a known skin or respiratory sensitizer
Other Information: Restricted to professional or industrial use, not intended for general consumer products
Eco-Toxicity: Moderately toxic to aquatic organisms based on structural analog data
Persistence and Degradability: Readily biodegradable under aerobic conditions
Bioaccumulation: Low bioaccumulation potential
Mobility in Soil: Moderate mobility, leaching can occur in sandy or loose soils
Other Adverse Effects: Avoid releases into waterways due to potential for local oxygen depletion
Waste Treatment Methods: Dispose of in accordance with local, regional, and national regulations
Disposal Containers: Use tightly sealed, labeled chemical waste containers
Additional Measures: Contact licensed chemical waste disposal contractor, do not discharge to sewer systems or surface water
UN Number: Not classified as a hazardous material for transport
Proper Shipping Name: 4’-Hydroxyacetophenone
Transport Hazard Class: Non-regulated
Packing Group: Not assigned
Environmental Hazards: Not a marine pollutant
Special Precautions: Ensure packaging prevents spillage and dust formation during transit
OSHA Status: Not specifically regulated
TSCA Inventory: Listed
European Regulations: In compliance with REACH, not classified as a substance of very high concern
SARA Title III: Not subject to reporting under Sections 302, 304, or 313
Other International Regulations: Compliant with major chemical control regulations, local legislation may provide additional handling and reporting requirements
