Product Name: 1,8-Diaminooctane
Synonyms: Octamethylenediamine, Octane-1,8-diamine
CAS Number: 373-44-4
Molecular Formula: C8H20N2
Molecular Weight: 144.26 g/mol
Manufacturer: [Company Name or Supplier’s Contact Information]
Recommended Use: Intermediate for organic synthesis, used in production of polymers, curing agents, and specialty chemicals
Emergency Contact: [Insert Emergency Contact Number]
Restriction on Use: Industrial use only, not for food, drug, or household applications
Classification: Corrosive to skin and eyes (Skin Corr. 1B), Acute Toxicity Oral and Dermal (Category 4), Respiratory Sensitizer (Category 1)
Hazard Statements: Causes severe burns and eye damage. Harmful if swallowed, inhaled, or absorbed through skin. May cause an allergic skin reaction.
Pictograms: GHS05 (Corrosion), GHS07 (Harmful), GHS08 (Health hazard)
Signal Word: Danger
Precautionary Statements: Do not breathe dust, vapors, or mist. Wash thoroughly after handling. Wear protective gloves, clothing, eye and face protection. Avoid release to the environment.
Routes of Exposure: Eyes, skin, inhalation, ingestion
Primary Symptoms: Severe irritation or burns, pain, redness, blistering, possible permanent eye injury
Chemical Name: 1,8-Diaminooctane
CAS Number: 373-44-4
Concentration: >98% by weight
Impurities: Water (<1%), minor amine-related byproducts
Other Components: None significant affecting hazard classification
Inhalation: Move to fresh air. Keep patient at rest. Seek immediate medical advice for any breathing difficulty. Provide oxygen if breathing becomes difficult.
Skin Contact: Remove contaminated clothing. Immediately rinse skin under running water for 15 minutes. Seek prompt medical attention for persistent pain or burns.
Eye Contact: Rinse eyes cautiously with water for several minutes. Remove contact lenses if present. Seek urgent medical attention for any discomfort or visual disturbance.
Ingestion: Rinse mouth with water. Do not induce vomiting. Never give anything by mouth to an unconscious person. Seek immediate medical advice.
Most Important Symptoms: Burning sensation, coughing, redness, blistering, burns, respiratory distress
Advice for Physician: Treat as corrosive substance exposure; monitor airway and respiratory function, provide supportive care
Suitable Extinguishing Media: Dry chemical, CO2, water spray, or foam
Unsuitable Extinguishing Media: High-pressure water jet (may spread material)
Specific Hazards: Emits toxic and corrosive fumes such as nitrogen oxides and ammonia when heated to decomposition
Protective Equipment: Full firefighting gear, self-contained breathing apparatus
Special Protocols: Isolate fire area, evacuate downwind, use water spray to cool containers exposed to flames
Hazardous Combustion Products: Smoke, carbon oxides, nitrogen oxides, ammonia
Flammability: May burn but does not ignite easily under normal conditions
Personal Precautions: Wear protective gloves, goggles, and clothing. Provide adequate ventilation. Avoid breathing vapors or contact with skin and eyes.
Environmental Precautions: Prevent spillage from entering drains or watercourses. Try to contain spillage using non-combustible absorbent material.
Clean Up Methods: Absorb with inert material, such as sand or earth, then transfer to closed containers for disposal. Wash affected area with plenty of water after clean-up.
Methods for Containment: Avoid splashing, ensure proper disposal of contaminated material.
Decontamination: Ventilate and wash spill area after material pickup
Handling: Open containers carefully. Use only in well-ventilated areas. Do not breathe vapors, mists, or dusts. Avoid contact with skin and eyes. Wear suitable protective clothing.
Hygiene Practices: Wash hands before breaks, at end of shift, and after handling. Do not eat, drink, or smoke while handling chemical.
Storage Conditions: Store tightly closed in a cool, dry, well-ventilated area away from acids, oxidizers, and foodstuffs. Keep container upright and tightly sealed.
Incompatibilities: Strong acids, strong oxidizers, acid chlorides, acid anhydrides
Specific Storage Hazards: Protect from physical damage. Ensure secondary containment for large volumes.
Packaging Materials: Use corrosion-resistant, compatible materials for containers
Occupational Exposure Limits: No national occupational exposure limit established, but minimize exposure as far as possible
Engineering Controls: Use local exhaust ventilation if available. Ensure wash stations and emergency showers are close to the work area.
Respiratory Protection: Use NIOSH/MSHA approved respirators for high concentrations or accidental releases.
Eye/Face Protection: Chemical safety goggles and face shield
Skin Protection: Wear chemical-resistant gloves (nitrile or neoprene) and full protective clothing
Hygiene Measures: Change contaminated clothing immediately, wash thoroughly after handling
Physical State: Solid
Appearance: White to pale yellow crystalline powder
Odor: Ammonia-like odor
pH: Approximately 11 (1% solution in water)
Melting Point: 45–49°C
Boiling Point: 238–242°C at 760 mm Hg
Flash Point: 140°C (closed cup)
Evaporation Rate: Not volatile at ambient temperature
Flammability: Combustible
Explosion Limits: No data available
Vapor Pressure: 0.01 mm Hg at 25°C
Solubility: Soluble in water, alcohols; insoluble in ethers and hydrocarbons
Partition Coefficient: Log Pow ≈ -1.0
Vapor Density: Not determined
Relative Density: 0.90–0.95 g/cm³
Viscosity: Not determined
Chemical Stability: Stable at standard temperature and pressure with normal handling
Reactivity: Reacts strongly with acids, acid chlorides, and acid anhydrides; forms ammonia-like vapors
Hazardous Reactions: Can undergo violent reaction with oxidizing agents
Conditions to Avoid: Heat, flame, ignition sources, direct sunlight, and incompatible substances
Materials to Avoid: Strong acids, oxidizers, acid halides
Hazardous Decomposition Products: Ammonia, nitrogen oxides, carbon monoxide, carbon dioxide
Polymerization: Will not occur under normal conditions
Acute Toxicity: Oral LD50 (rat): 400 mg/kg; Dermal LD50 (rabbit): 750 mg/kg
Chronic Effects: Prolonged exposure causes dermatitis, respiratory sensitization, and possibly liver or kidney effects
Carcinogenicity: Not listed by IARC, NTP, or OSHA as known or suspected carcinogen
Acute Effects: Pain, redness, corrosion, ulceration on skin and eye contact; respiratory tract irritation if inhaled
Mutagenicity: Not expected based on available data
Reproductive Toxicity: No conclusive data
Other Information: Sensitization reactions possible on repeated skin contact
Potential Routes of Entry: Inhalation, ingestion, or skin/eye contact
Aquatic Toxicity: Harmful to aquatic life at moderate concentrations; LC50 (fish, 96hr): 11 mg/L
Persistence and Degradability: Readily biodegradable yet toxic to organisms during initial breakdown
Bioaccumulation Potential: Low; Log Pow suggests minimal accumulation in living tissue
Mobility in Soil: Highly mobile in water when released; soluble and can leach
Ecotoxicological Effects: Adverse impact on aquatic invertebrates, possible long-term harm in water environments
Other Adverse Effects: Significant pH increase in water may injure aquatic organisms
Waste Disposal Methods: Dispose of as a hazardous waste according to local, state, and federal laws
Contaminated Packaging: Rinse containers thoroughly before disposal, follow proper procedures for hazardous residues
Incineration: At high-temperature permitted facilities with appropriate controls
Landfill: Only permitted for neutralized or inert waste
Precautions: Neutralize any residue with dilute acid under controlled conditions before disposal
UN Number: UN 2734
UN Proper Shipping Name: Amines, liquid, corrosive, n.o.s. (1,8-Diaminooctane)
Transport Hazard Class: 8 (Corrosive materials)
Packing Group: II (Medium danger)
Marine Pollutant: Not classified as a marine pollutant but avoid release to environment
Special Precautions: Secure containers to prevent leaks. Keep compatible materials separated during transport
Label Requirements: Corrosive placard required for bulk shipments
TSCA Status: Listed on the Toxic Substances Control Act inventory
DSL/NDSL (Canada): Substance present
EU REACH Status: Registration possibly required if importing more than 1 ton/year; check current ECHA status
SARA 313 (U.S.): Not subject to reporting, not listed as a significant environmental release hazard
OSHA Status: Regulated as hazardous, subject to general workplace safety standards
WHMIS Classification (Canada): D2B (Toxic), E (Corrosive material)
Other Relevant Regulations: Subject to workplace right-to-know laws in many jurisdictions
Labeling Requirements: Follow all hazard communication standards for labeling and safety data disclosure
