Product Name: 1,6-Dichlorohexane
Chemical Formula: C6H12Cl2
CAS Number: 2163-00-0
Synonyms: Hexamethylene dichloride, Hexylene dichloride
Recommended Use: Organic synthesis, chemical intermediate
Manufacturer: Refer to product supplier
Emergency Phone Number: Refer to national poison center or local emergency services
Classification: Flammable liquid, Category 3; Skin irritation, Category 2; Eye irritation, Category 2A; Specific target organ toxicity – single exposure, Category 3
Signal Word: Warning
Hazard Statements: Causes skin and serious eye irritation, suspected of causing respiratory irritation, harmful if inhaled, may cause drowsiness or dizziness, flammable liquid and vapor
Precautionary Statements: Keep away from heat/sparks/open flames. Avoid breathing vapor, prevent skin and eye contact, use with adequate ventilation, wear suitable personal protection
Chemical Name: 1,6-Dichlorohexane
CAS Number: 2163-00-0
Concentration: ≥99%
Impurities: May include traces of other chlorinated hexanes (less than 1% total)
Inhalation: Move exposed individuals to fresh air. Seek medical attention if symptoms such as coughing, shortness of breath or dizziness occur.
Skin Contact: Remove contaminated clothing immediately, wash area with plenty of water and soap. Consult a doctor if irritation continues.
Eye Contact: Flush eyes with water for at least 15 minutes, lifting the eyelids occasionally. Obtain emergency medical assistance.
Ingestion: Rinse mouth thoroughly, do not induce vomiting. Seek urgent medical advice. Never give anything by mouth to a person who is unconscious.
Suitable Extinguishing Media: Use foam, dry chemical powder, or carbon dioxide for small fires. Water spray can help cool exposed containers.
Unsuitable Extinguishing Media: Direct water streams may spread burning liquid.
Hazards from Combustion: Releases hydrogen chloride, phosgene, carbon monoxide, carbon dioxide when burned.
Protective Equipment: Firefighters need self-contained breathing apparatus and full protective gear.
Special Information: Containers may build pressure and explode when heated. Cool containers with water until fire is out.
Personal Precautions: Ventilate area. Evacuate unnecessary personnel. Use chemical-resistant gloves, safety goggles, and protective clothing to avoid contact.
Environmental Precautions: Prevent run-off into sewers, waterways, or soil. Notify authorities if large spills enter the environment.
Containment: Stop leak if safe. Dike area to contain spill. Absorb with inert material like sand, vermiculite, or earth.
Cleanup: Scoop absorbed material into suitable containers for disposal. Clean area with water and detergent after collection.
Handling: Work in a chemical fume hood if possible. Avoid splashes and formation of vapors or aerosols. Do not eat, drink or smoke when handling.
Storage: Store in tightly sealed containers in a cool, dry, well-ventilated location away from heat sources, sparks, and incompatible materials including oxidizers, strong acids, and bases.
Incompatible Materials: Avoid contact with strong oxidizing agents, alkali metals, and strong bases as violent reactions can develop.
Special Precautions: Keep containers closed and properly labeled. Use grounding and bonding for bulk storage. Inspect regularly for leaks.
Occupational Exposure Limits: No established limits specific for 1,6-dichlorohexane; use general limits for chlorinated hydrocarbons
Engineering Controls: Use mechanical exhaust or local ventilation to minimize vapor exposure.
Eye Protection: Chemical safety goggles or face shield.
Skin Protection: Chemical-resistant gloves (nitrile or neoprene), lab coats or coveralls.
Respiratory Protection: Use approved respirators with organic vapor cartridges if exposure risk exists.
Hygiene Measures: Wash hands after handling. Remove contaminated clothing and clean before reuse.
Appearance: Colorless to pale yellow liquid
Odor: Mild, sweet, chlorinated solvent odor
Boiling Point: 211–213 °C (411–415 °F)
Melting Point: -18 °C (0 °F)
Flash Point: 92 °C (198 °F) (Closed cup)
Vapor Pressure: 0.5 mmHg at 20 °C
Solubility: Nearly insoluble in water; miscible with many organic solvents
Density: 1.094 g/cm³ at 20 °C
Viscosity: 2.16 mPa·s at 25 °C
Partition Coefficient (log Kow): 3.8
Stability: Stable under normal ambient and anticipated storage conditions.
Decomposition: Can generate toxic or corrosive gases like hydrogen chloride on high heat or contact with strong acids.
Reactivity: Vigorous or violent reaction possible with strong bases, oxidizers or alkali metals.
Hazardous Polymerization: Not anticipated under proper use.
Conditions to Avoid: Elevated temperatures, sources of ignition, strong sunlight, uncontrolled mixing with incompatible chemicals.
Acute Toxicity: Moderate acute toxicity if inhaled or absorbed through skin; oral LD50 in rats approximately 2000 mg/kg.
Inhalation: May cause headache, dizziness, drowsiness, nausea. High concentrations can cause unconsciousness.
Skin Contact: Causes irritation, redness, and possible dermatitis.
Eye Contact: Direct contact can result in severe redness, stinging, and damage.
Chronic Effects: Repeated exposure can lead to liver and kidney effects in laboratory animals.
Other Potential Hazards: Animal data show possible central nervous system depression.
Toxicity to Aquatic Life: Classified as toxic to aquatic organisms; LC50 (fish, 96hr) 2–6 mg/L.
Persistence and Degradability: Low biodegradability in water under aerobic conditions.
Bioaccumulation Potential: High potential, estimated log Kow 3.8 suggests tendency to accumulate in aquatic life.
Mobility in Soil: Moderately mobile, could leach to groundwater depending on soil properties.
Other Adverse Effects: Long-lasting hazards to aquatic environments.
Waste Disposal Methods: Dispose as hazardous waste according to local, state, and federal regulations. Incineration in chemical incinerators with afterburner and scrubber preferred.
Containers: Triple rinse empty containers before recycling or disposal. Never reuse for food or drink.
Precautions: Do not allow spill residues to reach natural waterways. Obtain permitted hazardous waste contractor for large volumes.
UN Number: UN 2810
Proper Shipping Name: Toxic liquid, organic, n.o.s. (contains 1,6-Dichlorohexane)
Hazard Class: 6.1 (Toxic substance)
Packing Group: III
Labels Required: Toxic, environmental hazard
Special Transport Notes: Follow all applicable DOT, IMDG, IATA regulations. Keep containers upright and secure during transit.
U.S. TSCA: Listed
OSHA: Regulated as toxic and hazardous
SARA Title III: Subject to reporting under Section 313 for release of chlorinated hydrocarbons
Canada (DSL/NDSL): Listed
WHMIS Classification: D1B (Toxic material), D2B (Irritant)
EU Classification: Hazardous according to Regulation (EC) No 1272/2008 (CLP/GHS)
Other National Regulations: Check specific local environmental release and workplace safety rules.
